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1.2.1.3 Formation of Medium-Sized Rings (7 to 11)

DOI: 10.1055/sos-SD-221-00020

Jammi, S.; Nottingham, C.; Guiry, P. J.Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016173.

As the ring size increases, the preference for the endo mode of cyclization increases. This is due to the more flexible tether in these larger rings generating a more energetically favorable transition state for endo, which is not possible for smaller ring sizes.


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