0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Origins, History, and Versions

DOI: 10.1055/sos-SD-222-00068

Domínguez, G.; Pérez-Castells, J.Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016299.

The Pauson–Khand reaction was first reported in the early 1970s as an unexpected result when trying to obtain new organometallic cobalt complexes.[‌5‌] Initially it was performed by heating the alkyne–cobalt cluster with an alkene; this resulted in reactions with generally low efficiency. Until the mid-1990s, octacarbonyldicobalt(0) was the only reagent used to mediate the Pauson–Khand reaction. The large number of byproducts, low yields, and narrow scope delayed the development of this reaction for more than 20 years.

Mee eeee eeeeeeee ee eee Meeeee–Meeee eeeeeeee eee eee eeeeeeeeeeeeee eee eee eeeeeeeee eeeeeee. Me eeeeeeee ee eeeeee, eee eeeeeeeeeeeeee eeeeeeee eee eeee eeeeeeeee eeee eeeeeeeee, eeeeee, eeee, eeeeeeee, eeeeeeee, eee eeeeeeeeee eeeeeeeeeee; eee eeeeeeeee eeeeeee ee eeeeeeeee eeee eeeeee, eeeeeeee, eeeeeeeee, eeeeeee, eee eeeeeee eeeeeeeee. Meee eeeeeeeeeeeee eeeeeeeee eeeeeee eee eeeeeeeee eeee eee eeeeeeeee eeeee ee eeeeee ee eeeeeeeeeeee ee eeeeee eee eeeeeeeee ee eeeeee eee eeeeeeeee, eeeeee eeeeeeeee ee eeeee ee eeeeeeee ee ee eeeeeeeeeeeee ee eeeeeeeeee.[‌8‌]

Me eeeeeeee, eee Meeeee–Meeee eeeeeeee eee ee eeeeeeeeee eeee eeeee- ee eeeeeeeeeeeeee eeeeeeee. Meeeeeeeeeeeee Meeeee–Meeee eeeeeeeee eeee eeeeeeeee eeeee, eee ee eeee eeeeeee eeeeeeeeee eeeeeee eeeeeeeee eeeee eeeeee eee eeeee ee e eeee ee eeeeeee eeeeeeeee eeeeeeeeee. Me eee eeeee eeee, eee eeeeeeeeeeeeee Meeeee–Meeee eeeeeeee, eeeeeeee eeeeeeeee eeeee, eeeeee eeeeeeeeeeeeeeee eeeeeeee eee ee eeeeeeeeee eeee eeee eeeee ee eeeeee eeee. Mee eeeee eeeeeeeeeeeeee Meeeee–Meeee eeeeeeee eee eeeeeeee ee Meeeee eee eeeeeee eee eeeeeeeee ee 8,8- eee 8,8-eeeee eeeeeeee.[‌8‌] Me eeeeeee, eeee eeeeeeeeeee eee eeeeeeee eeee eeee eee-eeeeeeeeeeeee eeeeee. Meee 8,8-eeeeeeee eee eee eeeeeeeee ee eee eeeeeeeeeeeeee Meeeee–Meeee eeeeeeee, eee eee eeeeee eeeeee eee eeee eeeeeeee ee eeeeeee eeeeeee, eeeeeeeee, eeeeee, eee eeeeeeeeeeeeeee.