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2.6.1 (2 + 2 + 2) Cycloadditions of Alkynes

DOI: 10.1055/sos-SD-222-00161

Tanaka, K.; Shibata, Y.Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (20162266.

The transition-metal-catalyzed (2 + 2 + 2) cycloaddition of alkynes enables the synthesis of densely substituted benzenes and has been most actively investigated. A wide variety of transition-metal catalysts and alkynes have been employed in this transformation. When the reactions allow the use of two or three different alkynes, a diverse array of substituted benzenes can be synthesized in a single step by simply changing the combination of substituted alkynes. Furthermore, various non-centrochiralities (axial, planar, and helical chiralities) can be constructed through the ring formation by using chiral transition-metal complexes as catalysts.