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Please login to access the full content or check if you have access via2.6.1 (2 + 2 + 2) Cycloadditions of Alkynes
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Tanaka, K.; Shibata, Y., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 266.
The transition-metal-catalyzed (2 + 2 + 2) cycloaddition of alkynes enables the synthesis of densely substituted benzenes and has been most actively investigated. A wide variety of transition-metal catalysts and alkynes have been employed in this transformation. When the reactions allow the use of two or three different alkynes, a diverse array of substituted benzenes can be synthesized in a single step by simply changing the combination of substituted alkynes. Furthermore, various non-centrochiralities (axial, planar, and helical chiralities) can be constructed through the ring formation by using chiral transition-metal complexes as catalysts.
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