0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
2.9.7 Conclusions and Future Perspectives

DOI: 10.1055/sos-SD-222-00230

Mondal, M.; Bora, U.Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (20162531.

Although tremendous progress has been achieved in the field of radical cyclization reactions for selective organic synthesis, numerous areas remain unexplored. In recent years, radical reactions have evolved into many general areas in organic, inorganic, materials, supramolecular, and polymer chemistry. The present status of radical processes may be attributed to the groups of Julia, Walling, Ingold, Beckwith, Hart, Stork, Houk, RajanBabu, Mulliken,[‌472‌] Kagan,[‌175‌] Taube,[‌473‌] Marcus,[‌474‌] Huber,[‌475‌] Kochi,[‌476‌] Ashby,[‌477‌] Pross,[‌478‌] Evans,[‌479‌] Giese,[‌36‌] Curran,[‌37‌] Roy, Chakraborty, Snider, Demir, Molander, Gansäuer, Nishino, and many more. The strategies developed so far have already begun to display their utility in a wide range of applications ranging from the preparation of significant biologically active compounds or their precursors to agrochemicals and pharmaceuticals. With the advantages of higher yields and higher stereoselectivities relative to those obtained in the equivalent cationic reactions, radical cyclizations have been applied in the efficient synthesis of many (poly)cyclic skeletons that are valuable synthons in numerous synthetic approaches. Moreover, relative to their cationic counterparts, radical-bioinspired protocols are often characterized by their unique chemo- and regioselectivities. Nevertheless, some methods still suffer from certain drawbacks and need further research. For instance, the development of general methods for the synthesis of large families of organic products might be more productive than specific procedures restricted to the preparation of only one or a few compounds. Furthermore, titanium(III)-based radical cyclizations do not allow the synthesis of cis-fused carbocycles, which are essential elements of many natural products.

Me eeeeeeeee ee eeee eeeeeee, eeeeeeeee(MMM)-eeeeeeeee eeeeeeeee eeeeeeeeeee eeeeeeeeee eeeeeee eee eeeeeeeeeee eeeeeee ee eeeeeeee eeeeeeee eeee eeeeeeee eeeeee, eeeeeeeeeee eeeeeeeeeeee, eeeeeeeeeeee, eeeeeeeeeeeeeeee, eee eeeeeeeeeeeee, eeeee eeeeeeeeeee eeeeeeeeeeeeee eeeeeeeee eeee eeeee eeeeeeee ee eeeeeee eeeeeeee. Meee eeeeeee eee eeeeeeeee eeeeeeee eeeeeeeeeeee ee eeeeeee eeeeeeeee eeeeeee ee eeeeeeeee(MMM)-eeeee eeeeeeeeee.

Meeeeeeee, eeeeeeee(MM) eeeeee eee eeeeeee ee ee eeeeeeeee eeeeeeee eeeeeee eee eee eeeeeeeeeeeeee eeeeeeeee ee e eeeeeee ee eeeeeeeeee eeeeee eeeeeee eeee-eeeee eeeeeeee eeeeeeee. Mee eeeeeeeee eeeeeeeee ee eeeeeee, eeeeeeee eeeeee, eeeeeeeeee eeee eeeeeeeeeee, eeeeeeeee, eeeeeee, eee eeeeeeeeee–eeeeeeeeee eeeee ee eeeee e eeee-eeeeeeeee eeee. Meeeeee, eeeeeeee ee eeeeeee eeeeeeee(MM)-eeeee eeeeeeeee eeeeeee eeee eeee eeeeeee eee eeeeeeeee eeeeeeeee eeeeeeeeee eeee eeee ee ee eeeeeeeeee ee eee eeee eeeeee.

Meeeeeeeee(MMM)-eeeeeeee eeeeeee eeeeeeeee eeee eeee eee ee eeeeeeeeeee eeeeeeee ee eee eeeeeeeee ee eeeeeee eeeeeeee ee eeeeeee eeeeee eee eeeeeeeeee eeeeeeeee. Meee eeeeeeeee eee eeeeeeee ee eeeeeeeeee-eeeee eeeeeeeeeeeeeeee, eeeeee eeee eeeeeeee ee (eeee)eeeeee eeeeeee eeeeeeeee. Me eeeeeeeeee, eee eeeeeeeeeee eeeeeeeee ee eeeeeeeeeeeee eeeeeee eeeeeeeee ee eeee eeeeeeeeeee ee eeeeeee eeeeeeeeee eeeeeee ee eeeeeeee(MMM) eeeeeeeee. Meeeeeee, eeeeeee-eeeee eeeeeeeeeee eeeeeeeee eee eeee eeeeeeeeeeeee ee eeeee eeeeeeeeeee eeeee- eee eeeeeeeeeeeeeeeeee, eeeee eee eeeee eeeeee eeee eeeee eeeeeeee ee eeeeeeee eeeeeeeeeee eeeeeeeee. Meee eee eeeeeeeeeeee ee eeeeeeee eeeeeeeee[‌888‌‌888‌] ee eeeeeeee eeeeeeeee, eee eeeeeeeeeee ee eeeeeee eeeeeeeee eeee eeeeeee eeeeeee eeeeeee eeeeeeeee eee eeeeee eeeeeeeeee eeeeeeee. Meee, eeeee eeeeeeee eeee eeeeeee eeeeeeee eee eeeeeee ee eee eeeeeee ee eeeeeeeee eeeeeee eeeeeeee ee eee eeee eeeeee.