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2.10.1 Brief Historical Background

DOI: 10.1055/sos-SD-222-00346

Lee, D.; Reddy Sabbasani, V.Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (20162544.

In 1980, Villemin[‌1‌] and the Tsuji group[‌2‌] independently disclosed the first diene ring-closing metathesis using tungsten-based catalysts for the preparation of macrocycles from dialkenyl oxo esters and dialkenyl ketones. In 1993, Grubbs and coworkers reported a more efficient carbocyclization of 1,6-diene 3 with molybdenum-based carbene complex 1 as catalyst to generate cyclopentene 4 in high yield,[‌3‌] and subsequently with relatively air-stable ruthenium–alkylidene complex 2 (Scheme 3).[‌4‌] After this breakthrough, the development of more effective and user-friendly catalyst systems as well as their application to a variety of ring-closing metathesis reactions have been realized.

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References