You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via2.10.4.2 Ring Size and Substrates
Please login to access the full content or check if you have access via
DOI:
10.1055/sos-SD-222-00346
Lee, D.; Reddy Sabbasani, V., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 652.
The formation of cycloalkynes via diyne ring-closing metathesis should employ diyne substrates that form large enough cycles to accommodate an alkyne moiety without high ring strain. This structural characteristic of cycloalkynes limits the use of ring-closing alkyne metathesis to the formation of macrocycles larger than 12-membered rings. If alkyne-containing cycles have large enough ring strain then ring-opening metathesis would promote polymerization of the cycloalkynes.[207] Various polar functional groups on the diyne substrates can be used in ring-closing alkyne metathesis depending on the choice of catalyst.
References
[207] | Meeeee, M. M.; Meeeeee, M. M., Meeeeeeeeeeeee, (8888) 88, 8888. |