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1.2.1.1.3 Suzuki–Miyaura Reactions in Water Catalyzed by Palladium–N-Heterocyclic Carbene Complexes

DOI: 10.1055/sos-SD-223-00045

Chetcuti, M. J.Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (20161113.

In recent years there has been a push toward safer and less-polluting catalysis and this tendency has also been observed in the Suzuki–Miyaura reaction. This has manifested itself in the increase in the number of publications appearing in which the solvent is water or where the catalytic system is immobilized on a solid support. The heterogenization of molecular NHC catalysts is covered in Section 2.7, but here some of the most pertinent examples of palladium–NHC catalysis of the Suzuki–Miyaura reaction in water, leading to environmentally benign systems (or at least steps that move in that direction), are presented.

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