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1.2.3.2 Coupling Reactions Involving (Het)Aryl Bromides and Iodides

DOI: 10.1055/sos-SD-223-00066

Martin, A. R.Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (20161172.

The ability of a metal catalyst to insert into carbon—halogen bonds is obviously correlated to the catalyst itself and also, importantly, to the nature of the halide. Carbon—chlorine bonds are known to be less reactive than carbon—bromine and carbon—iodine bonds. Following this general trend, the protocols described in Section 1.2.3.1 that allow the arylation of various amines using aryl chloride reagents could undoubtedly also be performed with aryl bromide and aryl iodide reagents. Nevertheless, there are few reports of the use of catalytic systems with aryl bromides and iodides.[‌43‌‌45‌]

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