Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
1.2.3.2.1 Palladium Catalysis

DOI: 10.1055/sos-SD-223-00066

Martin, A. R.Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (20161172.

As discussed in Section 1.2.3.2, the palladium-based catalytic systems presented in Section 1.2.3.1.1 are also able to promote the arylation of various amines using aryl bromide reagents. Moreover, as exemplified in Scheme 14, it is possible to take advantage of the higher reactivity of bromides compared to chlorides for chemoselective amination at a carbon—bromine bond in the presence of a carbon—chlorine bond, even if the former position is more hindered, as in the example of the reaction of 2-bromo-5-chlorotoluene with 2,6-dimethylaniline which gives N-(4-chloro-2-methylphenyl)-2,6-dimethylaniline (33).[‌9‌]

Meeeee 88 Meeeeeeeeeeeee Meee Meeeeeeee[‌8‌]

References


Cookie-Einstellungen