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2.1.4.7 Challenging Enyne Substrates and Relay Metathesis

DOI: 10.1055/sos-SD-224-00028

Diesendruck, C. E.Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016294.

As in any chemical reaction, some substrates are unreactive or provide very low yields. In enyne metathesis, the reasons behind this low reactivity are usually steric hindrance and/or electron-withdrawing groups on the alkene or alkyne.

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