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2.6.1 Carboxylation

DOI: 10.1055/sos-SD-224-00164

Nelson, D. J.Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (20162281.

Methods for the carboxylation of various substrates have received significant attention recently, particularly due to the value of the products (such as carboxylic acids) and the potential to deploy carbon dioxide, which is inexpensive and readily available. While it has long been known that carbon dioxide will react with nucleophilic organometallic reagents (such as organolithium species), the challenge is to allow for the mild and selective carboxylation of a range of compounds, particularly ones that might bear sensitive functional groups.


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