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2.6.1.1 Carboxylation of C—H Bonds Catalyzed by Gold(I) Hydroxide Complexes

DOI: 10.1055/sos-SD-224-00164

Nelson, D. J.Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (20162281.

Gold(I) hydroxide complexes bearing N-heterocyclic carbene (NHC) ligands, first disclosed in 2010 by Nolan and co-workers,[‌1‌] can be activated in situ by acid to form cationic gold species without the need for silver salts (Scheme 1).[‌2‌] Alternatively, they have also provided an opportunity for other mechanistic manifolds in gold catalysis, as they can react with suitably acidic C—H bonds to yield new organogold species.

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