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8.1.6.4 Oxidation of 1,2-Diols to α-Hydroxy Acids and Further Oxidation to α-Oxo Acids

DOI: 10.1055/sos-SD-225-00271

Dornan, L. M.; Hughes, N. L.; Muldoon, M. J.Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (20171559.

α-Hydroxy acids are a valuable functionality and one that can be prepared via the direct oxidation of readily available 1,2-diols. Shibuya and co-workers have published two reports, one that describes the oxidation of 1,2-diols to α-hydroxy acids[‌57‌] and a second which shows that α-hydroxy acids can be further oxidized to the α-oxo acids.[‌58‌]

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References