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11 Nickel in Photocatalysis

DOI: 10.1055/sos-SD-229-00192

Kelly, C. B.; Matsui, J. K.; Phelan, J. P.; Gutiérrez Bonet, Á.; Lang, S. B.; Molander, G. A.Science of Synthesis: Photocatalysis in Organic Synthesis, (20181339.

General Introduction

The tremendous contribution of metal-catalyzed cross coupling [C(sp2)–C(sp2), C(sp)–C(sp2), etc.] to charting new chemistry territory is virtually unparalleled. Such processes have granted access to a multitude of novel compounds and enabled construction of several “blockbuster” pharmacons. However, notable gaps exist in current cross-coupling protocols for accessing the three-dimensional space often required for successful drug candidates.[‌1‌] The stark difference in the structure of medicinal compounds is striking when comparing synthetic versus naturally occurring compounds. Scheme 1 shows the structures of the synthetic anti-cancer agent imatinib (Gleevec; Novartis) and antibiotic ciprofloxacin (Ciprobay; Bayer) along with the naturally occurring anti-cancer agent taxol (Paclitaxel; Bristol-Myers Squibb) and antibiotic erythromycin (Ilosone; Eli Lilly).

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References


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