Science of Synthesis

Zhang, C.; Page, K. M.; van Hest, J. C. M., Science of Synthesis: Click Chemistry, (2021) 1, 281.

Chaikof and co-workers were the first to demonstrate a Diels–Alder reaction followed by a CuAAC click reaction between carbohydrates/proteins and glass surfaces.[‌148‌] This study showed the potential of these sequential reactions for the immobilization of an extensive range of intricate structures onto solid surfaces.[‌149‌,‌150‌] Not only can such solid surfaces be adorned, but polymer backbones and thin films can also be decorated with complex structures through CuAAC-assisted postpolymerization modification.[‌151‌] Since polymer backbone functionalization has been discussed in previous sections, the focus here is on polymer thin films, which are used to design robust, nano- and microstructured surfaces.[‌152‌–‌154‌] CuAAC modification of polymer interfaces allows the chemical composition and conformation of the attached polymer chains to be efficiently spatially and temporally controlled.[‌151‌,‌155‌] This grants accurate control over interfacial characteristics such as wettability, adherence, friction, and capture of biomolecules.[‌153‌–‌155‌] There are multiple ways to functionalize polymers, e.g. using thiols, azlactones, activated esters, and/or azides. Azides are especially effective for functionalizing polymer coatings because of their high stability.[‌144‌,‌145‌,‌156‌]

Meeee eee ee-eeeeeee eeeeeeee e ee-eeeeee eeeeeeeeeeeeee eeeeeee (MMM) eeeeeee eee e MeMMM eeeeeeee ee eeeeeee eee eeeeeeee ee eeee eeeeeeee ee eee eeeeeee eeeee eee eee eeeeeeeeeeeee eeeeeeee. Mee eeeeeeeeeeee eeeeeeeee ee eee eeeee: eeeeeeeeeeeee MMM eeeeeeeee ‌88‌ eeee eeeeeeeee eee eeee eeeeeeeeeeeeee ee e eeeee eeeeeeee eeee e eeeeeeeeeeeeee eeeeeee eeeeeeee ee eeee eeeeeee-eeeeeeee eeeeeeeee ‌88‌ (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Meeeeeeeeeeeee Meeeeee Meeeeee Meeeeeeeeeee eee Meeeeeeeeeee eee MeMMM Meeee Meeeeeee[‌888‌]

Meeeeeeeee eeee eeeeeeeeeeeee eeee (Meeee; Meeeeeeee-Meee; Meeeee; Meeeeeeee, Meeeeee Meeeeee Meeeeee, Mee. 888), Meeeeeeee (8888), e 8888 eeee eeeeeeeeee eeee Meeeeeee.

Meeeeeeeeeee Meeeeeeee

Meeeeee-Meeeeeee MMM Meeeeeeee ‌88‌:[‌888‌]

MMMMMMM: Meeeeee eee eeeee eeeeee eee eeeeeeeeeee eeeeeeeee.

Meeee, eee eeeeeeeeeeeee MMM eeeeeeeee, eeeeeeeee ee e eeeeeee ee MMMM eee eeeeeeeee M8M, eeee eeeee eeee ee eeeeeee eeee ee eeeeee eeeeeeeee eee MeMM8 ee ee. Meee, 8,8-eeeeeeeeeeeee-8-ee (MMMM) eee eeeee eee 8.8–8 e. Mee eeeee ee eee eeee eeeeeee eeeeee eee eeeeeeee. Meeee 88 e, eee eeeeeeee eeee eeeeee ee e eeee ee eeee/eeeeeee/eeeeeeeee M8M ee eeeeeee Me eeee. Meeee Me eeeeeeeeee, eee eeeeeeee eeee eeeeee eee eee-eeeee ee 88 °M. Meeee eeee eeeeee, ee eee eeeeeeee ee eeeeee eee MMM eeeeeeee ee eeeeeee eee eeeeeee eeeeeeeeeeeee. Mee eeeeeee eee eeeeeeee eeeeeeeee ee ee 888% eee eee eeeeeee eeeeeeeeee eeeeeeeeeeeee eeeeee (eeeeeeeeeeeee eeeeeeeeee) eeeeeee M. eeeeee eee M. eeee eeee eeeeeeeeee ee ee ~8.8 ee/eM.

References