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5 Sulfur Fluoride Exchange (SuFEx)

DOI: 10.1055/sos-SD-235-00230

Giel, M.-C.; Smedley, C. J.; Moses, J. E.Science of Synthesis: Click Chemistry, (20211435.

General Introduction

Sulfur(VI) fluoride exchange (SuFEx) is a new-generation click reaction that was launched by Sharpless and co-workers in 2014. SuFEx is a powerful technology for forging stable covalent linkages with absolute reliability,[‌1‌,‌2‌] exploiting a unique blend of stability and latent reactivity that characterize high-oxidation-state SF functionalities [e.g., S(VI)]. The advantage of controlled reactivity through catalyst tuning, coupled with the thermodynamic and redox stability of the SF group, in stark contrast to their more common SCl counterparts, are critical features of SuFEx click chemistry.

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