Science of Synthesis

Wang, X.; Lu, X., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 238.

‌Meeeee 8‌ Meeeee-Meeeeeeee Meeeeeeee M(ee8)—M Meeeeeeeee ee e MMM-Meeeee Meeeeeeeeeeeeeeeeeeeee eeee Meeeeeeeeeee[‌88‌]

‌Meeeee 8‌ Meeeee-Meeeeeeee Meeee-Meeeeeeeeeeeeee Meeeeeee ee e MMM-Meeeee Meeeeeeeeeeeeeeeeeeeee eeee Meeeeee[‌88‌]

‌Meeeeeeeeee 8‌

M8	Meeee (%)	Mee
Me	88	[‌88‌]
8-MeMM8M8	88	[‌88‌]
8-M8MM8M8	88	[‌88‌]
8-M8MM8M8	88	[‌88‌]
8-MeM8M8	88	[‌88‌]
8-eeeeeee	88	[‌88‌]
8-(MM≡M)M8M8	88	[‌88‌]
MMM	88	[‌88‌]
MM8MMMee	88	[‌88‌]
	88	[‌88‌]
(MM8)8M≡MM	88	[‌88‌]

‌Meeeee 88‌ Meeeee-Meeeeeeee Meeee-Meeeeeeeeeeeeee Meeeeeee ee e MMM-Meeeee Meeeeeeeeeeeeeeeeeeeee eeee e Meeeee Meeeee[‌88‌]

‌Meeeee 88‌ Meeeee-Meeeeeeee Meeee-Meeeeeeeeeeeeee Meeeeeee ee e MMM-Meeeee Meeeeeeeeeeeeeeeeeeeee eeee Meeeeee[‌88‌]

‌Meeeeeeeeee 88‌

‌Meeeee 88‌ Meeeee-Meeeeeeee Meeee-Meeeeeeeeeeeeee Meeeeeee ee e MMM-Meeeee Meeeeeeeeeeeeeeeeeeeee eeee Meeeeeee Meeeeeeee[‌88‌]

‌Meeeee 88‌ Meeeee-Meeeeeeee Meeee-Meeeeeeeeeeeeee Meeeeeee ee e MMM-Meeeee Meeeeeeeeeeeeeeeeeeeee eeee Meeeeeeeeeeeee Meeeeee[‌88‌]

Meeeeeeeeeee Meeeeeeee

Me-MMM 8-(Meeeeeeeeee)-8,8,8,8-eeeeeeeeeeeeeeeeeeeeeee, e.e. ‌88‌; Meeeeee Meeeeeeee:[‌88‌]

Me ee Meeeeeeee eeee eeee eeeee e 8 eM eeee ee eee MMM-eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8 µM, 8 eeeee), ee 888 eM eeee ee MeMM8 ee MeMM (8.88 µM, 8888 eeeee), e 8 eM eeee ee (MeMMe)8•eeeeeee ee MeMM (88 µM, 8 eeeee), eee e 8 eM eeee ee e-MeMMM ee MeMM (8 µM, 8 eeeee). Mee eeeeeeeee eeeeeee eee eeeeeeee eee eeee eeee ee eeeee ee 88 °M eee 88 e. Meeee eeeeeeeeee, e 888 eM eeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8.8 µM) eee eeeee ee eee eeeeeee, eeeee eee eeeeee ee 88 °M eee ee eeeee 88 eee. Mee eeeeeeeee MMM-eeeeee eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeee.

Me-MMM 8-Meeeeee-8,8,8,8-eeeeeeeeeeeeeeeeeeeeeee ‌88‌; Meeeeee Meeeeeeee:[‌88‌]

Me ee Meeeeeeee eeee eeee eeeee ee 888 eM eeee ee eee eeeeee ee MeMM (8.88 µM, 8888 eeeee), e 8 eM eeee ee (MeMMe)8•eeeeeee ee MeMM (88 µM, 8 eeeee), eee e 8 eM eeee ee e-MeMMM ee MeMM (8 µM, 8 eeeee). Mee eeeeeee eeeee eeee eee eeeeeeee eee eeeeeeeeeee. Meee, ee e 8 eM eeee ee eee MMM-eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8 µM, 8 eeeee) ee eeeeeee Meeeeeeee eeee eee eeeee 8 eM MMMM ee MeMM (8 µM, 8 eeeee). Meeee 8 eee ee eeeeeeeeee, eee eeeeeee eeeee eeeeee/(MeMMe)8•eeeeeee/e-MeMMM eeee eee eeeee. Mee eeeeeeeee eeeeeee eee eeeeeeee eee eeee eeee ee eeeee ee 88 °M eee 88 e. Meeee eeeeeeeeee, e 888 eM eeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8.8 µM) eee eeeee ee eee eeeeeee, eeeee eee eeee eeeeee ee 88 °M eee ee eeeee 88 eee. Mee eeeeeeeee MMM-eeeeee eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeee.

Me-MMM 8-(8-Meeeeeee)-8,8,8,8-eeeeeeeeeeeeeeeeeeeeeee, e.e. ‌88‌; Meeeeee Meeeeeeee:[‌88‌]

Me ee Meeeeeeee eeee eeee eeeee e 8 eM eeee ee eee MMM-eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8 µM, 8 eeeee), ee 888 eM eeee ee eeeeeeeeeeee ee MeMM (8.88 µM, 8888 eeeee), eee e 8 eM eeee ee (MeMMe)8•eeeeeee ee MeMM (88 µM, 8 eeeee). Mee eeeeeeeee eeeeeee eee eeeeeeee eee eeee eeee ee eeeee ee 88 °M eee 88 e. Meeee eeeeeeeeee, e 888 eM eeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8.8 µM) eee eeeee ee eee eeeeeee, eeeee eee eeeeee ee 88 °M eee ee eeeee 88 eee. Mee eeeeeeeee MMM-eeeeee eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeee.

Me-MMM 8-(8M-Meeee-8-ee)-8,8,8,8-eeeeeeeeeeeeeeeeeeeeeee, e.e. ‌88‌; Meeeeee Meeeeeeee:[‌88‌]

Me ee Meeeeeeee eeee eeee eeeee e 8 eM eeee ee eee MMM-eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8 µM, 8 eeeee), ee 888 eM eeee ee eee eeeeee ee MeMM (8.88 µM, 8888 eeeee), eee e 8 eM eeee ee (MeMMe)8•eeeeeee ee MeMM (88 µM, 8 eeeee). Mee eeeeeeeee eeeeeee eee eeeeeeee eee eeee eeee ee eeeee ee 88 °M eee 88 e. Meeee eeeeeeeeee, e 888 eM eeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8.8 µM) eee eeeee ee eee eeeeeee, eeeee eee eeeeee ee 88 °M eee ee eeeee 88 eee. Mee eeeeeeeee MMM-eeeeee eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeee.

Me-MMM 8-(Meeeeeeeeeeeeeeeeee)-8,8,8,8-eeeeeeeeeeeeeeeeeeeeee ‌88‌:[‌88‌]

Me ee Meeeeeeee eeee eeee eeeee e 8 eM eeee ee eee MMM-eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8 µM, 8 eeeee), ee 888 eM eeee ee (MeM)8MMM ee MeMM (8.88 µM, 8888 eeeee), eee e 8 eM eeee ee (MeMMe)8•eeeeeee ee MeMM (88 µM, 8 eeeee). Mee eeeeeeeee eeeeeee eee eeeeeeee eee eeee eeee ee eeeee ee 88 °M eee 88 e. Meeee eeeeeeeeee, e 888 eM eeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8.8 µM) eee eeeee ee eee eeeeeee, eeeee eee eeeeee ee 88 °M eee ee eeeee 88 eee. Mee eeeeeeeee MMM-eeeeee eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeee.

Me-MMM 8-Meeee-8,8,8,8-eeeeeeeeeeeeeeeeeeeeee ‌88‌:[‌88‌]

Me ee Meeeeeeee eeee eeee eeeee e 8 eM eeee ee eee MMM-eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8 µM, 8 eeeee), ee 888 eM eeee ee MMMMM ee MeMM (8.88 µM, 8888 eeeee), eee e 8 eM eeee ee (MeMMe)8•eeeeeee ee MeMM (88 µM, 8 eeeee). Mee eeeeeeeee eeeeeee eee eeeeeeee eee eeee eeee ee eeeee ee 88 °M eee 88 e. Meeee eeeeeeeeee, e 888 eM eeee ee eee eeeeeeeee eeeeee eeeeeeeeeeeeeeeeeeeeee ee eeM8M (8.8 µM) eee eeeee ee eee eeeeeee, eeeee eee eeeeee ee 88 °M eee ee eeeee 88 eee. Mee eeeeeeeee MMM-eeeeee eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeee.

References