You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via2.7.2 Summary and Outlook
Please login to access the full content or check if you have access via
Liu, G.; Feng, J., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 347.
On-DNA cyclization reactions are important chemical transformations for the construction of aromatic and nonaromatic ring systems for library synthesis without requiring tremendous effort to preform complex scaffolds. In addition, in some cases, a large number of commercially available building blocks can be used to achieve on-DNA cyclization. These include primary amines and aldehydes used in benzimidazole DELs (see Section 2.7.1.1) and primary amines used in indazolone DELs (see Section 2.7.1.2). Hence, the synthetic strategy of on-DNA cyclization reactions provides an attractive avenue to build highly diverse ring-system-cored DELs with appropriate decorations.
Return to Top