Science of Synthesis

Willems, S.; Brunschweiger, A., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 355.

‌Meeeee 8‌ Meeeeeeee ee MMM–MMM–Meeeeeee Meeeeeeeee ee Meeee Meeeeeee[‌8‌–‌8‌]

Meeeeeeeeeee Meeeeeeee

MMM–Meeeeeee Meeeeeeeee ‌88‌ (‌Meeeee 8‌); Meeeeee Meeeeeeee eee Meeeeeeee ee Meeee Meeeeeee:[‌8‌–‌8‌]

Meeee Meeeeeeeeeee: MMM-eeeee MMM ‌8‌ (eeeeee MMM ee eeMMM; 8–88 ee ee eeeee-eeeee eeeeeeee, ~88 eeee/ee) eee eeeeee eeee e eeeeeeeee eeeeee eee eeeeee ee e eeeeee eeeeeeee. Meee, 8% Me8MMM8M ee MeMM ee MM8Me8 (888 µM) eee eeeee eeee 88–88 e eee eee eeee eeeeee ee eeeeee eeeee. Mee eeeee eee eeeeee eeee 8% Me8M ee MeMM (888 µM), eee eee eeeeeeee ee Me8MMM8M ee eee eeeee eeeee eee eeeeeeee eeeee ee eeeeeee eeeeeeee ee eee eeee eee eeeeeeee. Meeeeee, MMM-eeeee MMM eee eeeeeeeeeee eeee 8% Me8M ee MeMM eee eeeeee eeeee eeeee eeee MMM, MeMM, MeMM, eee MM8Me8 (eeee 888 µM) eee eeeee ee ee eeeee eeeeeee eeeeeeee ee e eeeeee eeeeeeee.

Meeee Meeeeeee: Meeeee eee eeeeeeee eee eeeeeee, MMM-eeeee MMM (eeeeee MMM ee eeMMM), eeeeeeeeeee eeeeeeeeee eeee ‌88‌, eee MMMM eeee eeeee eeeee eeee eeeeee eeeeee e eeeeeeeeee eee 88 eee. Meeee eeeee eeeee (8.88 M ee eeeee MMM) ee eeeeeeeeee eeee ‌88‌ eee MMMM eeee eeeeeeee. Meee e 8.8-eM Meeeeeeee eeee eeee eeeee eeeee ee eeeeeeeeee eeee ‌88‌ (88 µM, 88 µeee, 888 eeeee), MMMM (88 µM, 88 µeee, 888 eeeee), eee eMe8MMe (88.88 µM, 88.8 µeee, 888 eeeee). Mee eeeeeee eee eeeeee ee 8888 eee eee 8 eee eee eeeee ee e 8-eM Meeeeeeee eeee eeeeeeeeee eeeeeeeeeee MMM-eeeee MMM (8–88 ee, 88 eeee/ee, 8 eeeee) eeeeeeeee ee eeeee MMM (88 µM). Mee eeeeeee eee eeeeee ee eeeeeee eeeeeeeeeee eee 8 e. Meee, eee MMM-eeeee MMM eeeeeeeee eee eeeeeeeeeee ee e eeeeeeeee eeeeee, eeeee eee eeeeee ee e eeeeee eeeeeeee, eee eee eeeee-eeeee eeeeeeee eee eeeeee eeeee eeeee eeee MMM, MeMM, MeMM, eee MM8Me8 (eeee 888 µM) eee eeeee eeeee eeeeeee eeeeeeee ee eee eeeeee eeeeeeee. Me eeeeee eeee eeeeeeeeee, eee eeeeeeee eee eeeeeeee eeee. Mee eeeeeeee eeeeeee eee eeeeeeee ee eeeeeeee e eeeee eeeeeee ee eee MMM-eeeee MMM eeeeeeeee (~8.8 ee, 88 eeee/ee) eeee eeeee MMM eeee (88% MM8 ee M8M/88% MeMM8 ee M8M, 8:8; 888 µM) ee e 8.8-eM Meeeeeeee eeee eee 8 e ee eeeeeee eeeeeeeeeee. Meeeeeeeee, 8 M Meee eeeeee (eM 8.8; 88 µM) eee eeeee ee eee eeeeeee, eee eee eeeeeeee eeeeeeee eeee eeeee eeeeeee eeeee eeeeeee eeeeeeee ee 88 °M. Mee eee eeeeeeee eee eeeeeeeee ee eeeeeeeee M8M (888 µM) eee eeeeeeee eeeeeee e eeeeeee eeeeee, eeeee eee eeeeee eeee eeee eeeeeeeee M8M (888 µM). Mee eeeeeeeee eeeeeeee eee eeeeeeee ee MM-MMMM eee MMMMM-MM. Me eeee ee eee eeeeeeeeee ee eee eeeeeee (<88%), eee eeeeeeee eee eeeeeeee e eeeee eeee. Meeeeee, eee eeeeeeeee MMM-MMM eeeeeeeee ‌88‌ eee eeeeeee eeeee eeeee ee e eeeeee eeeeee eeeeee ee e eeeeee eeeeeeee eee 88 e eeee e eeeeeee eeeeeeee eeeeeeee ee eeeeeee eeeeeee (888 µM), eeeeeeeeee ee e 8:8 eeeeeee ee MMM/8-eeeeeeeeeeeeeee (8:8) eee MMM/eeeeeeee/Me8M (8:8:8). Mee MMM-eeeee MMM eeeeeeeee eee eeeeee eeeee eeeee eeee MMM, MeMM, MeMM, eee MM8Me8 (eeee 888 µM) eee eeeee eeeee eeeeeee eeeeeeee ee eee eeeeee eeeeeeee.

References