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Georgiev, T.; Cazzamalli, S.; Neri, D.; Bassi, G., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 499.
This chapter provides an overview of the conventional methodologies to construct single-stranded DELs (ssDELs) and also elaborates on alternative approaches, such as chemical ligation (via CuAAC click reaction), DNA-templated synthesis, and photo-switching of DEL headpieces. The construction of good quality and large ssDELs relies heavily on robust iterative encoding methodologies. The splint-assisted ligation is now routinely used for the efficient construction of DNA-recorded DELs.
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