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DOI: 10.1055/sos-SD-241-00212

Farrera-Soler, L.; Vummidi, B. R.; Barluenga, S.; Winssinger, N.Science of Synthesis: DNA-Encoded Libraries, (20241546.

The reported screening is based on three selection rounds, with increased stringency in each round. Nonetheless, depending on the characteristics of the protein, as well as on the expected affinity of the library members, the stringency of the selection (quantity of protein vs. library, number/temperature/duration/buffer of washes, or the number of rounds of selection) may need to be adapted to obtain a more informative result.[‌15‌]

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