Science of Synthesis

Zhou, Y.; Huang, Y.; Xu, L.; Xiong, F., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 482.

Benefiting from the DNA duplex scaffold, double-stranded DNA-encoded libraries (dsDELs) exhibit superior stability for handling in an industrial context compared to single-stranded DNA-encoded libraries (ssDELs). Hence, the advent of dsDELs has greatly widened the use of DELs in the pharmaceutical industry and facilitates hit-compound identification against different diseases. This chapter provides an overview of the preparation of dsDELs and demonstrates common strategies using benzimidazole-based libraries as representative examples.

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