Science of Synthesis

Geng, J.; Sapkota, N.; Lin, S., Science of Synthesis: Abiotic Reactions in Live Environments, (2024) 1, 167.

General Introduction

Bioorthogonal chemistry represents the series of chemical reactions that can take place inside living organisms without disturbing their normal functions.[‌1‌] The concept of self-assembly, rooted in bioorthogonal chemistry, was pioneered several years ago. Initially, it was challenging to achieve controlled assembly with specific molecular weights and structures. However, recent advancements have largely overcome these obstacles, allowing molecules to self-assemble in a controlled manner inside living cells, while avoiding potentially hazardous elements that could disrupt the biological environment.[‌2‌] For instance, bioorthogonal copper-free click chemistry uses strain-promoted azide–alkyne cycloaddition (SPAAC) to form triazole linkages,[‌3‌] thereby avoiding the toxic effects of copper on cells that could interfere with cellular processes.[‌4‌]

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References