Science of Synthesis

Montgomery, J., Science of Synthesis, (2001) 1, 11.

General Introduction

This contribution provides an overview of contemporary synthetic methods of broad applicability that involve the preparation and use of nickel π-complexes as starting materials or reactive intermediates. Numerous excellent reviews on the chemistry of nickel have appeared that are complementary to this contribution in subject and scope. An outstanding review by Chetcuti describes the known π-complexes of nickel,[‌1‌] and several other structural classes of nickel complexes have been reviewed;[‌2‌–‌4‌] σ-bonded organonickel compounds are reviewed in Houben–Weyl, Vol. 13/9b, pp 632–700. The historical development and early applications of nickel chemistry have been reviewed by Wilke[‌5‌] and Jolly,[‌6‌] industrial applications have been reviewed by Keim,[‌7‌] and several other reviews on specific groups of synthetic transformations have appeared.[‌8‌–‌12‌,‌187‌] The organometallic chemistry of nickel has a rich history dating back more than 100 years.[‌5‌] Despite its long history, fundamentally new reactions are still being developed at a rapid pace. Furthermore, existing reactions are being applied in new and creative ways to solve long-standing challenges in organic synthesis. More and more of the synthetic organic community is beginning to realize that nickel catalysis provides preparatively convenient reactions of broad scope in a variety of contexts. In many cases, the reactivity exhibited by nickel may not be achieved by any other transition element. At this time, organonickel chemistry seems to be well poised to provide an increasing number of new reactions and interesting mechanistic questions, as well as to gain an increasingly important role in the organic chemist's repertoire of mainstream synthetic transformations.

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References