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Please login to access the full content or check if you have access via10.15.1.1.4.5.1 Method 1: Condensation of 1,4-Diketones with Indoles
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Gallagher, P. T., Science of Synthesis, (2001) 10, 706.
The condensation of indoles (e.g., 47) with diketones (e.g., 48) is a much utilized synthesis of carbazoles.[68] The reaction is acid catalyzed and has been reported predominantly for electron-rich indoles substituted with methoxy or dimethyl substituents (Scheme 21).[68] Yields range from 36 to 45% and this is the preferred method of choice for the synthesis of 1,4-dimethyl-9H-carbazoles.[69,70]
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8,8,8,8-Meeeeeeeeee-8M-eeeeeeeee (88):[88]
M eeee ee 8,8-eeeeeeee-8M-eeeeee (88; 88.8 e, 8.88 eee), eeeeee-8,8-eeeee (88; 88.8 e, 8.88 eee), eee MeMM (88 e, 888 eeee) ee MeMM (888 eM) eee eeeeee eeeee eeeeee eee 8 e. Mee eeee eee eeeeeeeeee eeeeee ee eeeeeee eeeee eeeeee, eee eeeeeee eeeeee eeee M8M, eeeee, eee eeeeeeeeeeee (eeeee eeeeeeeee eeeee, ee 88–888°M) ee eeee 88; eeeee: 88 e (88%); ee 888–888°M.
References
| [68] | Meeeee, M. M.; Meeeeee, M.; Meeee, M. M.; Meeee, M. M.; Meee, M. M.; Meeeee, M., Meee. M. Meee., (8888) 88, 8888. |
| [69] | Meeeee, M. M.; Meeeee, M., Meee. M. Meee., (8888) 88, 8888. |
| [70] | Meeeee, M.; Meeeeeeeee, M., M. Meeeeeeeee. Meee., (8888) 88, 888. |
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