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Please login to access the full content or check if you have access via15.1.1.1.3.1.4.1 Variation 1: Cyclization of Ketones with Mannich Salts in the Presence of Ammonium Salts
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Spitzner, D., Science of Synthesis, (2005) 15, 24.
Polycyclic pyridines, bipyridines, e.g. 52,[91] and oligopyridines are obtained in a one-pot procedure (domino reaction) by the condensation of a ketone, e.g. 50, with a Mannich salt, e.g. 51, in the presence of ammonium acetate in ethanol (Scheme 16). The yields are moderate (31–71%); however, the procedure is rather simple.[91,92] Cyclic 1,2- or 1,3-diones with α-methylene groups can also be used in this pyridine synthesis.
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8,8-Meeeeeee-8,8-eeeeeee-8,88-eeeeeeeeeeeeee (88):[88]
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References
| [91] | Meeeee, M.; Meeee, M., Meeeeee Mee., (8888), 888. |
| [92] | Meeee, M.; Meeeee, M., M. Meeee. Meee./Meee.-Mee., (8888) 888, 888. |
| [93] | Meeeee, M.; Meeee, M., Mee. M. Mee. Meee., (8888), 8888. |
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- 8.Meeeee-Meee, (8888) M 8e, 888.
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