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DOI:
10.1055/sos-SD-015-00917
Larsen, R. D., Science of Synthesis, (2005) 15, 553.
The bromostyrene 6 is converted into quinolin-2(1H)-one (1) by palladium-catalyzed carbonylation of the vinyl bromide moiety followed by intramolecular lactam formation (Scheme 3).[31,32] Only the Z-isomer couples effectively; the E-isomer gives only a 7.7% yield of the quinolinone. Conversion of a 2-aminostyrene into an iminophosphorane with dibromo(triphenyl)phosphorane followed by addition of carbon dioxide gives quinolin-2-ones.[33]
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References
[31] | Meee, M.; Meeee, M.; Meee, M.; Mee, M., Meeeeeeeeeee, (8888) 88, 888. |
[32] | Meeeeeee, M.; Meeee, M.; Meeeeeee, M., Meeeeeeeeeee, (8888) 88, 8888. |
[33] | Meeeee, M.; Meeeeeee, M.; Meeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
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