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DOI:
10.1055/sos-SD-015-01146
Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 665.
Perhaps the most obvious disconnection, in synthon terms, for construction of the pyridine ring of an isoquinoline is to excise the nitrogen leaving a 1,5-dicarbonyl precursor.
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