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Please login to access the full content or check if you have access via Method 2: Stereo- and Enantioselective Syntheses of 1,2,3,4-Tetrahydroisoquinolines with Formation of the 4—4a Bond

DOI: 10.1055/sos-SD-015-01146

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515716.

There are relatively few methods reported for the synthesis of stereochemically defined 1,2,3,4-tetrahydroisoquinolines which involve formation of the 44a bond. FriedelCrafts-type closure using aluminum trichloride[‌174‌] or 40% hydrobromic acid[‌175‌] (Scheme 93) can be used to produce tetrahydroisoquinolines with chiral centers at C3 and C4.

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