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Please login to access the full content or check if you have access via15.5.1.1.1.5.1.2 Method 2: Stereo- and Enantioselective Syntheses of 1,2,3,4-Tetrahydroisoquinolines with Formation of the 4—4a Bond
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DOI:
10.1055/sos-SD-015-01146
Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 716.
There are relatively few methods reported for the synthesis of stereochemically defined 1,2,3,4-tetrahydroisoquinolines which involve formation of the 4—4a bond. Friedel–Crafts-type closure using aluminum trichloride[174] or 40% hydrobromic acid[175] (Scheme 93) can be used to produce tetrahydroisoquinolines with chiral centers at C3 and C4.
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References
| [174] | Meeeeeeeeeeee, M.; Meeee, M. M.; Meeee, M. M.; Meeeeeeee, M.; Meeeeeee, M.; Meeeee, M. M.; Meeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [175] | Meóeee, M.; Meeeeeee, M.; Meeeeeeeeee, M. M., Meeeeeeeeee: Meeeeeeee, (8888) 88, 8888. |
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