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Please login to access the full content or check if you have access via Variation 1: From N-Acyl-2-aryl-2-hydroxyethylamines: Pictet–Gams Modification of the Bischler–Napieralski Synthesis

DOI: 10.1055/sos-SD-015-01146

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515720.

The modification introduced by Pictet and Gams[‌193‌,‌194‌] allows the direct synthesis of an aromatic isoquinoline 212, although the starting materials 210 are not quite as straightforwardly available. The presence of a hydroxy (or methoxy) group at the future isoquinoline C4 means that following ring closure, a simple dehydration (or loss of methanol) from 211 gives the aromatic molecule 212 (Scheme 97).

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