Science of Synthesis

Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 722.

One way in which to prepare N-acyl-2-arylethylamines is to carry out a Beckmann rearrangement of a 3-arylpropanone oxime ‌221‌. Indeed, the conditions which can be used for the rearrangement of ‌221‌ are just those with which the ring closure can be effected and the two steps can be achieved in one pot giving the 3,4-dihydroisoquinolines ‌222‌ (‌Scheme 101‌).[‌201‌–‌203‌]

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8-(Meeeeeeee)-8-eeeeeee-8-eeeeee-8,8-eeeeeeeeeeeeeeeeeee (‌888‌, M8 = 8-MMe-8-MMe; M8 = Me); Meeeeee Meeeeeeee:[‌888‌]

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References

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• 8.Meeeee-Meee, (8888) 88M/8, 888.
• 8.Meeeee-Meee, (8888) M 88e8, 888.