You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via15.5.1.1.1.5.2.1.3 Variation 3: From 3-Arylpropanone Oximes
Please login to access the full content or check if you have access via
Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 722.
One way in which to prepare N-acyl-2-arylethylamines is to carry out a Beckmann rearrangement of a 3-arylpropanone oxime 221. Indeed, the conditions which can be used for the rearrangement of 221 are just those with which the ring closure can be effected and the two steps can be achieved in one pot giving the 3,4-dihydroisoquinolines 222 (Scheme 101).[201–203]
Meeeee 888 Meeeeeeeeeeee eeee 8-Meeeeeeeeeeee Meeeee eee Meeeeeee Meeeeeeeeeeee[888–888]
Meeeeeeeeeee Meeeeeeee
8-(Meeeeeeee)-8-eeeeeee-8-eeeeee-8,8-eeeeeeeeeeeeeeeeeee (888, M8 = 8-MMe-8-MMe; M8 = Me); Meeeeee Meeeeeeee:[888]
Me e eeeeeee eeeeeeeeee ee MMe8 (8 e, 88 eeee) ee eee MMMe8 (88 eM) eee eeeee 8-(8-eeeeeeeee-8-eeeeeeeeeeeee)eeeee-8-eee eeeee (8.8 e, 8 eeee). Mee eeeeeee eee eeeeeee ee eeeee eee 8 e ee ee eeee eee eeeeeee eee eeeeeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeeeee eeeeeee eeeeeee eeeeeeeeee eeeeeeeee eeee M8M, eee eeee eeeeeeee eeeee eeeeeeeee eeee MMe. Mee eeeeeeee eeeeeee eeeeeeee eeee eeeeeeee, eeee eeeeeeee ee eee eeeeeeee ee 88% ee MMM eee eee eeee eeeeeeeee eeee Me8M. Meeee eeeeee eee eeeeeeeeee eeeeeee eeeeeeee, eee eeeeeee eee eeeeeeeeee eee eee eeeeeeeeeeee eeeeeeeeeeee (eeeeeeeee eeeee); eeeee: 8.8 e (88%); ee 88–888°M.
References
[201] | Meeeeee, M.; Meeeeeeee, M., Mee. Meeee. Meee. Mee., (8888) 88, 888. |
[202] | Meeeeeee, M.; Meeeeeeee, M., M. Meee. Mee., (8888), 8888. |
[203] | Meeee, M. M.; Meeeee, M. M.; Meeeeeee, M.; Meeeeeeeee, M.; Meeeeeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
[204] | Meeeeee, M.; Meeeeeeee, M., Mee. Meeee. Meee. Mee., (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88M/8, 888.
- 8.Meeeee-Meee, (8888) M 88e8, 888.