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Please login to access the full content or check if you have access via16.12.2.2.3.3 Variation 3: Reaction of 1,3-Oxazin-4-one with Thioamides
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von Angerer, S., Science of Synthesis, (2004) 16, 482.
Treatment of 6-methyl-2-phenyl-4H-1,3-oxazin-4-one with various thioamides in the presence of sodium hydride affords 6-substituted 5-acetylpyridin-4-ols 356 in good yields whereas the use of the corresponding amides results in far lower yields (Scheme 190).[440] This ring conversion can formally be regarded as a C—N—C—C + N—C pyrimidine-forming reaction.
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References
| [440] | Meeeeeee, M.; Meeee, M., Meeeeeeeeeee, (8888) 8, 8888. |
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- 8.Meeeee-Meee, (8888) M 8e8, 888.
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