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Seela, F.; Ramzaeva, N.; Rosemeyer, H., Science of Synthesis, (2004) 16, 1004.
The reactivity of halogen in the 2-, 6-, or 8-positions toward nucleophiles has made them amongst the most valuable of intermediates for the synthesis and interconversion of purines. Halopurines are generally prepared from hydroxy-, amino-, or sulfanyl-substituted purines by replacement of the substituents. By appropriate manipulation of the 2-tributylstannyl group in 2-(tributylstannyl)purines, 2-halopurine nucleosides are available in almost quantitative yields (70–100%).[321]
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References
| [321] | Meee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeeee, M.; Meeeeee, M.; Meeee, M.; Meeeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
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