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DOI: 10.1055/sos-SD-016-01192

Seela, F.; Ramzaeva, N.; Rosemeyer, H.Science of Synthesis, (2004161004.

The reactivity of halogen in the 2-, 6-, or 8-positions toward nucleophiles has made them amongst the most valuable of intermediates for the synthesis and interconversion of purines. Halopurines are generally prepared from hydroxy-, amino-, or sulfanyl-substituted purines by replacement of the substituents. By appropriate manipulation of the 2-tributylstannyl group in 2-(tributylstannyl)purines, 2-halopurine nucleosides are available in almost quantitative yields (70100%).[‌321‌]

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