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DOI: 10.1055/sos-SD-016-01192

Seela, F.; Ramzaeva, N.; Rosemeyer, H.Science of Synthesis, (2004161007.

8-Bromopurines 121 and their nucleosides can be obtained in a one-pot reaction by treatment of the corresponding precursors with bromine or N-bromoamides. If the substrate contains alkyl groups, then side-chain bromination is possible with most bromination reagents including bromine or N-bromosuccinimide. As side-chain halogenation is catalyzed by light, the reactions should be run in the absence of light whenever possible.

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Meeeeeeeeee 88

M8 M8 M8 Meeeeeeeee Meeee (%) Mee
MM MM8 Me M8M, ee, 8e 88 [‌888‌]
MM MM8 MM8M(MM8)8MM M8M, 8°M, 8e 88 [‌888‌]
MM MM8 8-eeeee-β-M-eeeeeeeeeeeee M8M, ee 88 [‌888‌]
MM MM8 8,8,8-eee-M-eeeeee-β-M-eeeeeeeeeeeee MeMM, MeMMe, 88°M, 8e 88 [‌888‌]
MM8 M 8,8,8-eee-M-eeeeee-β-M-eeeeeeeeeeeee MeMM, MeMMe, 88°M, 88e 88 [‌888‌]
MM8 M 8-eeeee-β-M-eeeeeeeeeeeee MeMMe, MeMM, M8M, eM8.8, ee, 8.8e 88 [‌888‌]
MM8 MM β-M-eeeeeeeeeeeee MeMM, MeMMe, ee, 8e 88 [‌888‌]
MM8 MM8 (MM8)8MMM8M(M)(MeMe)8 MMM, MMe8, ee, eeeeeeeee 88 [‌888‌]
MMMe M M 888°M, 8e 88 [‌888‌]
MMe8 M Me 8.8M MeMMe, ee, 8e 88 [‌888‌]

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Meeeeee eeeeeeeeeee ee 8-eeeee-8-(eeeeeeeeeeee)-8-(eeeeeeeeeeeeeee)eeeeee 888 eee eeeeeeeeeee ee eeeeeeee ee eee eeeee eeee M-eeeeeeeeeeeeeeee (Meeeee 88).[‌888‌]

Meeeee 88 Meeeeeeeeee ee Meeeeee eeee M-Meeeeeeeeeeeeeee[‌888‌,‌888‌,‌888‌]

Meeeeeeeeeee Meeeeeeee

8-Meeeeeeeeeeeeeeee (888, M8=MM8; M8=MM; M8=β-M-Meeeeeeeeeeee):[‌888‌]

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8-Meeee-8-(β-M-eeeeeeeeeeeee)-8M-eeeeee-8,8-eeeeeee (888):[‌888‌]

M eeeeeeeeee ee 8-(β-M-eeeeeeeeeeeee)-8M-eeeeee-8,8-eeeeeee (888ee, 8.88eeee) eee MMM (888ee, 8.88eeee) ee M8M (8.8eM) eee eeeeeee ee ee eee 8eee. Mee eeeeeee eee eeeeeee ee eeeee, eee eee eeeee eeeeeee eee eeeeeeeeeeeeeee (MM8Me8/MeMM 8:8); eeeee: 888ee (88%); ee 888°M.