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Please login to access the full content or check if you have access via Variation 8: Reaction with Alkenes and Alkynes Bearing Electron-Withdrawing Groups (Michael Addition)

DOI: 10.1055/sos-SD-019-00220

Murahashi, S.-I.Science of Synthesis, (200419354.

Using dihydridotetrakis(triphenylphosphine)ruthenium(II) as a catalyst, the Michael reaction of nitriles is also performed highly efficiently under neutral reaction conditions (Scheme 14). Thus, the addition of nitriles to α,β-unsaturated aldehydes proceeds chemoselectively.[‌42‌,‌43‌]

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Meeeeeeee (M)-8-Meeee-8-eeeeee-8-eeeeeeeeeeee (8); Meeeeee Meeeeeeee:[‌88‌]

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