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DOI: 10.1055/sos-SD-020-00532

Vanderwal, C. D.; Jacobsen, E. N.Science of Synthesis, (200720559.

The Perkin reaction for cinnamic acid synthesis is an acetic acid aldol equivalent that uses acid anhydrides as the aldol donors.[‌30‌] For example, treatment of aryl trifluoromethyl ketone 37 with acetic anhydride and sodium acetate leads to the formation of the alk-2-enoic acids 38 (Scheme 10).[‌31‌] In addition, this reaction can be used for the synthesis of α,β-disubstituted alk-2-enoic acids, as in the preparation of stilbene carboxylic acid 41 from substituted benzaldehyde 39 and arylacetic acid 40.[‌32‌]

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