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DOI:
10.1055/sos-SD-020-01227
Vanderwal, C. D.; Jacobsen, E. N., Science of Synthesis, (2007) 20, 1305.
General Introduction
The α,β-unsaturated ester function is of great utility and versatility in organic synthesis. Aside from its prevalence in natural products and medicinal agents, it serves as an important synthetic intermediate. Indeed, a wide range of conjugate addition processes and cycloaddition reactions enable the synthesis of much more complex compounds in which the ester group may be further manipulated. The synthetic flexibility of the ester function also provides access to numerous modes of reactivity. In this section, the most important and general methods for the introduction of the alk-2-enoic acid ester group will be discussed.
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