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You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content. Method 4: Wittig and Related Alkenylations

DOI: 10.1055/sos-SD-020-01227

Vanderwal, C. D.; Jacobsen, E. N.Science of Synthesis, (2007201320.

Certainly one of the most reliable methods for the introduction of the alk-2-enoic acid ester function is the homologation of aldehydes or ketones by Wittig and related condensation reactions. While the Wittig and HornerWadsworthEmmons reactions are most often used for this purpose, the HornerWittig and Peterson reactions have also successfully fulfilled this role.