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DOI: 10.1055/sos-SD-023-00535

Tidwell, T. T.Science of Synthesis, (200623588.

The thermolysis of ethyl ω-hydroxyalkynyl ethers 115 produces alkylketenes 116 by hydrogen transfer with elimination of ethene (Scheme 36).[‌94‌] The functionalized side chain bearing a pendant hydroxy group cyclizes intramolecularly to form the corresponding racemic lactones 117 (Scheme 36).[‌94‌] The addition of tributylamine (10 equiv) facilitates the cyclization reaction.

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