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Please login to access the full content or check if you have access via23.14.1.2.5 Method 5: Trifluoromethyl Ketones and Oxo Esters by Acylation of Monoalkylketenes with Trifluoroacetic Anhydride
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Tidwell, T. T., Science of Synthesis, (2006) 23, 601.
Tetradecylketene (176), generated by dehydrochlorination, undergoes electrophilic attack by trifluoroacetic anhydride, leading to a β-oxo mixed anhydride, which can be captured with methanol as the ester or hydrolyzed to the acid; the latter undergoes decarboxylation to form 1,1,1-trifluoroheptadecan-2-one (177) (Scheme 56).[117]
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References
| [117] | Meeeee, M.; Me Meee, M.; Meee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
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