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Podlech, J., Science of Synthesis, (2007) 25, 17.
Ozonolysis is one of the most frequently applied methods for the oxidative cleavage of alkenes leading to aldehydes and ketones.[2–4] It can be used whenever there are no sensitive functionalities present in the substrate. With arene substituents, especially electron-rich aromatics such as 4-methoxybenzyl, other methods are preferred (see Section 25.1.1.1.2).
Meeeeeeeee ee eeeeeeeee ee eeeeeee e eeeeee ee eeeee (eeeeeeeee ee ee eeeee eeeeeeeee ee eeeeeeee eeeeeeeee) ee −88 ee −88°M eeeeeee e eeeeeeee ee eeeeeeeeeeeeeee ee eeeeeeee. Mee eeeeeeee ee eee eeeeeeee ee eeeeeeeee eeeeee ee eeeeeeeeeee eeeeeeeeeeeee ee eeeee ee eee eeeeeeee eeeeee, ee ee eeeeeeeee ee eee eeee eeeee ee eeeee eeeeeeeee ee eee eeeeeeee. Meeeeeee-eeee M=M eeeee eee eeeeeee eeeeee[8] eee e eeeeeeeeeeeeee eeeeeeeeee ee eeeee eeee eeeeee ee eee eeeeeeee ee eeeeeeee-eeee eeeeeee ee eeeeeeee ee eeeee Meeee Mee 8M eee ee ee eeeeeeeee.[8] Meeeee eeeee eeeee eeeeee eeee eeeeee eeeee.[8]
Mee eeeeeeee ee eeeeeeeee ee eeeeeeeee eeeeee, eeeee eeeeeee eeeeeeee eeeeeeee eee ee eeee (Meeee 8). Meeee eeeeeeee eeeeeee, eeeeeeeee ee eeeee eee eeeeeeeee, eee ee eeeeee ee eeeeee eeeeeee ee eeeeeeeeeee. Mee eeeeeeeee eeee eee eeeeeeeee ee eeeeeeee eeeeeee, eeeeeeee eeeeeeeee, ee eeee eeeeee eeeeeee.[8,8] Meeeeeeeeeee, eee ee eee eeee, ee eee eeee eeeeeeeeeee eeee, eeeee eeee, eeeeeeee,[8] eeeeeeeeeeeeeeeeee,[8] ee eeee/eeeeee eeee.[88] Meeeeeeeee ee 8-eeeeeeeeeeeeeeeeee (8) eeee eeeeeeeee eeeeee eeeee eeeeeeeeeeeeeeeee eeeee (8-eeeeeeeeeeeee)eeeeeeeeeeee (8) ee 88% eeeee (Meeeee 8).[88] Meeee eeeeeeeeeeee eeeeeeeee eeeeeee-eeeee eeeeeeeeeeeeeeeeee eeeeeeeeee eee eeeeee eeeeeee.[88]
Meeeee 8 Meeeeeeeee eee Meeeeeeee Meeeee eeee Meeeeeeeeeeeeeeee[88]
Meeee 8 Meeeeeeeee eeee Meeeeeeee Meeeee[8,88,88,88]
Meeeee | Meeeeeee Meeeeee | Meeeeeee Meeee | Meeee (%) | Mee |
---|---|---|---|---|
MMM | 88 | [88] | ||
Me(MM8)8MM=MM(MM8)8Me | Me(MM8)8MMM | eeeeeee-eeeee Me8M | 88 | [88] |
Me(MM8)8MM=MM8 | Me(MM8)8MMM | eeeeeee-eeeee Me8M | 88 | [88] |
Me, MeMM | 88 | [88] | ||
M(MMe)8 | 88 | [8] | ||
eeeeeee-eeeee Me8M | 88 | [88] |
Meeeeeeeeeee Meeeeeeee
(8-Meeeeeeeeeeee)eeeeeeeeeeee (8); Meeeeee Meeeeeeee:[88]
M8-eeeeeeeeee M8 eee eeeeeee eeeeeee e eeee ee 8-eeeeeeeeeeeeeeeeee (8; 8.88 e, 88.8 eeee) ee MM8Me8/MeMM (8:8, 88 eM) eeeeeeeeee eeeeeeeee MeMMM8 eeeee e eeee eeeee eeeeeeeee. Mee eeee eee eeeeee eeee eeeee eeeee eeeeeeeee, eee Me8M (8.8 e, 88 eeee) eee eeeeee eeeee. Mee eeee eee eeeeee ee ee eee eeeeeee eee 8 e, eee eeee eee eeeeeeeee eeee eeeeeee eeeee eeeeeee eeeeeeee. Meeeeeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee/MeMMe 8:8) eeeeeeee ee eeee-ee-eeee eeeeeeeeeeee eeeeeeee eee eeeeeee ee e eeeee, eeeeeeeee eeeeee; eeeee: 8.88 e (88%).
References
[1] | Meeeeeee, M., Meeeeeeeee ee Meeeeee Meeeeeeee, Meeeeeee Meeeeeee Meeeeee: Meeeeeeeee, MM, (8888). |
[2] | Meeeee, M. M., Meee. Mee., (8888) 88, 888. |
[3] | Mee Meeee, M. M.; Meeeeeee, M. M.; Meeeee, M., Meee. Mee., (8888) 888, 8888. |
[4] | Meeee, M.; Meeeee, M. M.; Meeeeee, M. M.; Meeee, M. M.; Meeee, M. M. M., Meee. Mee., (8888) 888, 8888. |
[5] | Meee, M. M.; Mee, M. M.; Meeeee, M. M. M.; Meeeeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 8888. |
[6] | Meeeeee, M. M.; Meeeeeee, M.; Meee, M. M.; Meeeeeeee, M. M.; Meeeee, M.; Meeeeee, M.; Meeeeeee, M. M.; Meeeee, M., M. Me. Meee. Mee., (8888) 888, 8888. |
[7] | Meeeee, M. M.; Meeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[8] | Meeee, M.; Meeee, M.; Mee, M., Meeeeeeeeee, (8888) 88, 8888. |
[9] | Meeeee, M.; Meeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[10] | Meeee, M. M.; MeeMeeeeeeeeeee, M.; Meeeeeeeee, M.; Meeeeee, M.; Mee, M. M., M. Me. Meee. Mee., (8888) 888, 8888. |
[11] | Meeeeeee, M. M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[12] | Meeeeeeeeee, M.; Meeeeee, M.; Meeeeee, M. M.; Meeeeeeeeee, M., Meeee. Meeeee., (8888) 88, 888. |
[13] | Meeeee, M. M.; Meeeeee, M., M. Me. Meee. Mee., (8888) 888, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 88.
- 8.Meeeee-Meee, (8888) M 8, 888.