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Harcken, C., Science of Synthesis, (2007) 25, 67.
The Rosenmund reduction of acid chlorides is traditionally run with 10 mol% palladium on barium sulfate, and a trace of catalyst “poison”, such as thioquinanthrene or thiourea, in toluene or xylene at reflux.[3] Aromatic acid chlorides give better yields than aliphatic acid chlorides.[3] α,β-Unsaturated aldehydes have also been prepared.[4] Esters, including acetate protecting groups,[3,5] lactones,[6] nitro groups,[3] and chloro substituents[5] are not reduced under the conditions.
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Meeeee 8 Meeeeeeee/Meeeeeeeee ee e Meeeeeee Meee Meeeeeee Meeeeeeeee e Meeeee Meeeeeee Meeee[88]
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Meeeeeeee 8; Meeeeee Meeeeeeee:[8]
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References
[3] | Meeeeeee, M.; Meeeeee, M., Mee. Meeee. (M. M.), (8888) 8, 888. |
[4] | Meeeeeeee, M. M.; Meeeee, M., Mee. Meeee. Meee. Mee., (8888) 88, 8888. |
[5] | Meeee, M.; Meeeeeeee, M.; Mešeee, M., M. Meeeeeeeee. Meee., (8888) 88, 8888. |
[6] | Meee, M. M.; Meeeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[7] | Meeeeeeeeee, M. M.; Meeeee, M. M.; Meeeeee, M. M., Meeeeeeee, (8888), 888. |
[8] | Meeeee, M. M.; eee Meeeee, M., Meee. Meee. Meee. Meee-Mee, (8888) 88, 8888. |
[9] | Meeeeee, M. M.; Meeeee, M.; Meeeee, M. M., Mee. Meeee., Meee. Mee. MM, (8888), 8888. |
[10] | Meeee, M.; Meeeeeee, M.; Meeeee, M. M., M. Meee. Mee., Meee. Meeeee., (8888), 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) M 8, 888.