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26.1.4.6 Method 6: Synthesis from Amides

DOI: 10.1055/sos-SD-026-00142

Figadère, B.; Franck, X.Science of Synthesis, (200526275.

Dimethylamides, such as dimethylacetamide, were used as early as 1955/1956 for the acylation of alkyllithium and Grignard reagents to give the corresponding ketones in moderate to good yields.[‌212‌,‌213‌] Since then, many other amides have been used. N-Methoxy-N-methylamides (Weinreb amides), which are readily prepared and give high yields of ketones on acylation with several organometallic reagents, are now used extensively in ketone synthesis.[‌214‌]

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