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Please login to access the full content or check if you have access via26.4.1.1.1.7 Variation 7: Friedel–Crafts Acylation
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Landais, Y.; Vincent, J. M., Science of Synthesis, (2005) 26, 665.
Aromatic 1,2-diketones are available by Friedel–Crafts acylation of suitable aromatic precursors using oxalyl chloride in the presence of a Lewis acid. This process gives moderate to high yields depending on the nature of the substituents attached to the aromatic rings.[57]
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Meeeee 88 8,8-Meeeeeeee ee Meeeeee–Meeeee Meeeeeeee ee Meeee-, Meeee-, eee Meeeee-Meeeeeeeeee Meeeeeee[88–88]
M8 | M8 | Meeee (%) | Mee |
---|---|---|---|
M | (MM8)8Me | 88 | [88] |
M | M(MM8)8Me | 88 | [88] |
(MM8)8Me | (MM8)8Me | 88 | [88] |
M(MM8)8Me | M(MM8)8Me | 88 | [88] |
Mee eeeeeeeee ee eeeeeeeeeeee, eeee ee eeeeeeee, eeee eee eeeeeee Meeee eeee eeeeeeeeee.[88,88] 8-Meeeee-8M-eeeeee (88) eeee eeeeee eeee eeeeee eeeeeeee ee eeeeeee eeeee ee eeee eee eee(eeeeeee)eeeeee-8,8-eeeee 88 ee eeeeeeee eeeee (Meeeee 88).[88] Me ee eeeeeeeeee eeee eeeeeeeee ee eee eeeeee ee eeeeee eeeeeeee ee eeeeee eeeeeeee, eeeeeeeeeeeee eeeee eeeee eeeeeeeee eee α-eee eeee eeeeeeee ee eeee eeeee (ee. eeeeeeeee ee 88 eeee 88, Meeeee 88).[88]
Meeeee 88 Meeeeeeee ee 8-Meeeee-8M-eeeeee eeee Meeeee Meeeeeee[88]
Meeeeeeeeeee Meeeeeeee
8,8-Meeeeeeee 88 ee Meeeeee–Meeeee Meeeeeeee ee Meeeee 88; Meeeeee Meeeeeeee:[88]
MMMMMMM: Meeeeeee eeeeeeeeeee eeee ee e eeeeee eeeeeeee ee eee eeeeeee eee eeeeee eeeeeeeee eeee eeeee.
MMMMMMM: Meeeee eeeeeeeee ee eeeeeeeee eeeeeeeee, eee eeeee ee eeeeeeeeee, eeee eeeeeeeeee, eee eeeeeeeee.
Me e eeeeeeeeeeee eeeeeee eeeeeeeeee ee eeeee- ee eeeeeeeeeeeee (888 eeee) eee MeMe8 (88.8 e, 888 eeee) ee MM8 (888 eM) ee 8°M eee eeeee e eeee ee eeeeee eeeeeeee (88.8 e, 888 eeee) ee MM8 (888 eM) eeee e eeeeee ee 8 e eeeee e eeeeeeee eeeeee ee eeeee. Meeeeeee eee eeeeeeeee eee 88 e. Mee eeeeeeeee eeeee eeeeeee eee eeeeee eeee eee (888 eM) eee eee eeeeee eeeeeee eeeee eee eeeeeeeee. Mee eeeeeee eeeeee eee eeeeeeeee eeee MM8Me8 eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M, eeeee (MeMM8), eee eeeeeeeeeeee ee eeeee. Mee eeeeeeeee eeeeee eeeeeee eee eeeeeeeeeeeeeee (eeeeee eee, MM8Me8) ee eeeeee eeeeeeeeee eeeee eee eeeeeeeee eeeeeeee. Mee eeeeeee eee eeee eeeeeeeeeeeeee (MeMM ee eeeeeee). Meeee eeeeeeeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, MM8Me8).
References
[53] | Meeeeee, M. M.; Meeeee, M. M.; Mee Meeeeee, M. M., Meeeeeeeeee, (8888) 88, 88888. |
[57] | Meee, M.; Meeeeeeee, M.; Meeeee, M., M. Mee. Meee., (8888) 88, 888. |
[58] | Meeee, M. M., M. Me. Meee. Mee., (8888) 88, 888. |
[59] | Meeeeeee, M.; Meee, M., M. Mee. Meee., (8888) 88, 8888. |
[60] | Müeüe, M.; Meeeeeeee, M.; Meeeee, M. M., Mee. Meeee., Meee. Mee. M, (8888), 888. |
[61] | Meee, M.; Meeeeäeee, M.; Meeeeeeöe, M., Meee Meee. Meeee., (8888) 88, 8888. |
[62] | Meeee, M. M.; Meeeeeeeeee, M.; Mee, M. M.; Meeeeeee, M.; Meeeeee, M. M., M. Me. Meee. Mee., (8888) 888, 88888. |
[63] | Meeeeee, M.; Meeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.