0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Variation 7: Friedel–Crafts Acylation

DOI: 10.1055/sos-SD-026-00532

Landais, Y.; Vincent, J. M.Science of Synthesis, (200526665.

Aromatic 1,2-diketones are available by FriedelCrafts acylation of suitable aromatic precursors using oxalyl chloride in the presence of a Lewis acid. This process gives moderate to high yields depending on the nature of the substituents attached to the aromatic rings.[‌57‌]

Mee eee eeeeee eee ee eeeeeeeeee ee eeee ee eee eeeee eeeeeeee ee eeeeee eeeeeeee ee eeee eeeeeeee ee eeeeeeeeeeeeeeeeeee eeeeeee ee eeeeeeeee eeeeeeee. Meeeeeeeeeee, eeeeeeee-eeee eeeee-, eeeee-, eee eeeeee-eeeeeeeeeee eeeeeeee eeeeeeeeee eeeee eeeeeeeeee eeeeeeeeeee eeee eeeeee eeeeeeee ee eee eeeeeeee ee eeeeeeee eeeeeeeeeee ee eeeeee eeeeeeeee, eeeee ee eee eeeeeee ee eeeeee (Meeeee 88). Meeeeeeeeeeeee eeeeeeee eee eeeee ee eeeeeeeeeee ee eee eeeeeeeeeee ee 88 eeee 88.[‌88‌,‌88‌] Meeeeeeeeeeeee eeeeeeee ee eeeeeeee eeee ee M,M-eeeeeeeeeeeeeee eeee eeeeee eeeeeeee eeeee eee eeee eeeeeeeeee eeeeeee eee eeeeeee eeeeee 8,8-eeeeeeee, e.e. eee eee[8-(eeeeeeeeeeeee)eeeeee]-eeeeeeeeeee 8,8-eeeeeeee 88 ee eeeeeeee eeeee.[‌88‌] Meeeeeee ee eeeeee-eeeeeeeeeee eeeeee 88 eeeee eeeeee eeeeee ee eeeeeeeeeee eeeeee-eeeeeeeeeee 8,8-eeeeeeeee 88, eeeee eee eeeeeeeee ee eee eeeeee ee eee eeeee eeeee.[‌88‌] Meee-eeeee eeeeee eeee eeeeee eeeeeee eee ee eeeee eeeeee eeeeeeeeee ee eeeeee eeeeeeeee. Meeeeee, eeeeeeeeeeee ee eeeeee ee eee eeeee eeeeeeee eeeeeeee ee eee eeeeee eeeeeeeee eee ee eeeeeeee eeeee eeeee eeeeeeee eeeeeeeeee.[‌88‌]

Meeeee 88 8,8-Meeeeeeee ee MeeeeeeMeeeee Meeeeeeee ee Meeee-, Meeee-, eee Meeeee-Meeeeeeeeee Meeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 Meeee (%) Mee
M (MM8)8Me 88 [‌88‌]
M M(MM8)8Me 88 [‌88‌]
(MM8)8Me (MM8)8Me 88 [‌88‌]
M(MM8)8Me M(MM8)8Me 88 [‌88‌]

Mee eeeeeeeee ee eeeeeeeeeeee, eeee ee eeeeeeee, eeee eee eeeeeee Meeee eeee eeeeeeeeee.[‌88‌,‌88‌] 8-Meeeee-8M-eeeeee (88) eeee eeeeee eeee eeeeee eeeeeeee ee eeeeeee eeeee ee eeee eee eee(eeeeeee)eeeeee-8,8-eeeee 88 ee eeeeeeee eeeee (Meeeee 88).[‌88‌] Me ee eeeeeeeeee eeee eeeeeeeee ee eee eeeeee ee eeeeee eeeeeeee ee eeeeee eeeeeeee, eeeeeeeeeeeee eeeee eeeee eeeeeeeee eee α-eee eeee eeeeeeee ee eeee eeeee (ee. eeeeeeeee ee 88 eeee 88, Meeeee 88).[‌88‌]

Meeeee 88 Meeeeeeee ee 8-Meeeee-8M-eeeeee eeee Meeeee Meeeeeee[‌88‌]

Meeeeeeeeeee Meeeeeeee

8,8-Meeeeeeee 88 ee MeeeeeeMeeeee Meeeeeeee ee Meeeee 88; Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: Meeeeeee eeeeeeeeeee eeee ee e eeeeee eeeeeeee ee eee eeeeeee eee eeeeee eeeeeeeee eeee eeeee.

MMMMMMM: Meeeee eeeeeeeee ee eeeeeeeee eeeeeeeee, eee eeeee ee eeeeeeeeee, eeee eeeeeeeeee, eee eeeeeeeee.

Me e eeeeeeeeeeee eeeeeee eeeeeeeeee ee eeeee- ee eeeeeeeeeeeee (888eeee) eee MeMe8 (88.8e, 888eeee) ee MM8 (888eM) ee 8°M eee eeeee e eeee ee eeeeee eeeeeeee (88.8e, 888eeee) ee MM8 (888eM) eeee e eeeeee ee 8e eeeee e eeeeeeee eeeeee ee eeeee. Meeeeeee eee eeeeeeeee eee 88e. Mee eeeeeeeee eeeee eeeeeee eee eeeeee eeee eee (888eM) eee eee eeeeee eeeeeee eeeee eee eeeeeeeee. Mee eeeeeee eeeeee eee eeeeeeeee eeee MM8Me8 eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M, eeeee (MeMM8), eee eeeeeeeeeeee ee eeeee. Mee eeeeeeeee eeeeee eeeeeee eee eeeeeeeeeeeeeee (eeeeee eee, MM8Me8) ee eeeeee eeeeeeeeee eeeee eee eeeeeeeee eeeeeeee. Mee eeeeeee eee eeee eeeeeeeeeeeeee (MeMM ee eeeeeee). Meeee eeeeeeeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, MM8Me8).