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26.6.5.1.3 Method 3: Synthesis via Oxidative Addition to an Alkene

DOI: 10.1055/sos-SD-026-00761

Suffert, J.Science of Synthesis, (200526942.

Methods for the syntheses of α-hydroxy ketones from alkenes are limited to oxidations with zinc(II) permanganate supported on silica gel,[‌196‌] or potassium permanganate in presence of copper(II) sulfate.[‌197‌] The use of 2-methylpropanal and oxygen in the presence of osmium(VIII) oxide and bis(3-methypentane-2,4-dionato)nickel(II) catalyst as an efficient oxidative system is also described.[‌198‌] A more recent method employs an aqueous solution of ruthenium(III) chloride and peracetic acid.[‌199‌]

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