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Please login to access the full content or check if you have access via Method 4: Alkylidenation of Esters with Alkylidene Complexes of Titanium

DOI: 10.1055/sos-SD-032-00627

Milata, V.; Rádl, S.; Voltrová, S.Science of Synthesis, (200832661.

The use of titanium-based reagents to alkylidenate carbonyl groups is a well-known and widely used approach. The methylenation of aldehydes and ketones has a broader scope than other methods such as the Wittig reaction, but the principal advantage of this method is that it is possibile to alkylidenate carboxylic acid and carbonate derivatives.[‌192‌]